Synonym |
Thai / English name |
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : EGb 761 100 mcg/mlDuration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with EGb 761Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : ginkgolide A (GA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : GA 50 microMDuration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with GAType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : ginkgolide B (GB)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : GA 50 microMDuration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with GBType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : bilobalide (BB)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : BB 50 microMDuration : Human hepatocytes cultured in William's medium E (WME) were treated for 24 h with BBType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: In human hepatocytes, BB (50 microM), exhibited only modest effects on the expression of the tested human hepatic drug metabolizing enzymes (DMEs) and drug transporters.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : quercetin (Que)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Que 25 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with QueType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : kaempferol (Kae)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Kae 20 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with KaeType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : tamarixetin (Tam)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Tam 10 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with TamType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : EGb 761 100 mcg/mlDuration : HepG2 cells transfected with hCAR or hPXR expression vector were exposed to EGb 761 for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, Que and Kae induced CYP3A4 mRNA expression in human constitutive androstane receptor (hCAR)- and human pregnane X receptor (hPXR)- trasfected HepG2 cells trhough activation of these receptors.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : quercetin (Que)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Que 25 mcg/mlDuration : HepG2 cells transfected with hCAR or hPXR expression vector were exposed to Que for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, Que and Kae induced CYP3A4 mRNA expression in human constitutive androstane receptor (hCAR)- and human pregnane X receptor (hPXR)- trasfected HepG2 cells trhough activation of these receptors.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : kaempferol (Kae)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Kae 20 mcg/mlDuration : HepG2 cells transfected with hCAR or hPXR expression vector were exposed to Kae for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, Que and Kae induced CYP3A4 mRNA expression in human constitutive androstane receptor (hCAR)- and human pregnane X receptor (hPXR)- trasfected HepG2 cells through activation of these receptors.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin