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Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : Ginkgo biloba extract*Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Gingko biloba extract did not alter hCAR or hPXR mRNA expression. Whereas the extract (100 mg/ml) increased CYP2B6 mRNA and CYP2B6-mediated bupropion hydroxylation, the increase was not attenuated by the co-treatment with a hGR antagonist. The same pattern of response was also obtained for CYP3A4 mRNA and CYP3A-mediated testosterone 6b-hydroxylation. Therefore, Ginkgo biloba extract induces CYP2B6 (a hCAR target gene) and CYP3A4 (a hPXR target gene) by a hGR-independent mechanism.Note : *Solvent/active compound: Ginkgo extract (Lot A) 200 micrgram/mL consist ginkogolide A, B, C, J and bilobalide as 2.2, 0.6, 2.8, 1.2 and 5.6 microgram/mL, respectively.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : ginkgolide AType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with ginkgolide A (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : PositiveRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : ginkgolide BType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with ginkgolide B (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : PositiveRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : quercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with quercetin (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : NegativeRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : Standardized G. biliba extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatocyte The G. biloba ext. at 100-2,500 nanogram/mL significantly induced the activity, protein and mRNA expression of CYP3A in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : Standardized G. biliba extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 500 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatocyte The G. biloba ext. at 100-2,500 nanogram/mL significantly induced the activity, protein and mRNA expression of CYP3A in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : Standardized G. biliba extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2,500 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatocyte The G. biloba ext. at 100-2,500 nanogram/mL significantly induced the activity, protein and mRNA expression of CYP3A in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : bilobalideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatocytes Bilobalide at 2-50 ng/mL significantly increased CYP3A protein expression in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : bilobalideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatocytes Bilobalide at 2-50 ng/mL significantly increased CYP3A protein expression in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : bilobalideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 nanogram/mLDuration : 72 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatocytes Bilobalide at 2-50 ng/mL significantly increased CYP3A protein expression in a dose-dependent manner in human and rat primary hepatocytes.Note : Data incomplete
