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Part Used : ไม่ระบุActivity : CYP2E1 INDUCTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : -Result : NegativeRemark : Most reports unconfirmed. No effect on CYP1A2, CYP3A4, CYP2E1, CYP2D6 activity in humans, but moderate inducer of CYP2C19. Interaction reported with omeprazole in Chinese patients and fatal seizures in a patient on antieplilepsy medication. Caution if taken with warfarin, antiplatelet dugs, alprazolam, donezepil, trazodone, anticancer drugs.Note : Data from review, data incomplete.
Part Used : ใบActivity : CYP2E1 INDUCTIONSolvent/Active Compound : Ginkgo biloba leaf ext. (GBE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Fomepizole*/4-methylpyrazole/ 4MPDose/Conc.(drug) : -Result : NegativeRemark : The metabolism pathways involved for GBE were identified by preincubation of cryopreserved human primary hepatocytes (HPHs) with selective inhibitors of CYP2E1 (4-methylpyrazole).Note : Result: GBE showed the inhibition of PAF-induced platelet aggregation with IC50 of 33 mg/L-1, 30% enhancement over the control. These effects of GBE were reduced significantly by selectively inhibiting CYP1A2 but CYP2B6, 2C19, 2E1 and 3A4. The inhibitive effects of GBE on PAF induced platelet aggregation are regulated by CYP1A2. Data incomplete.
Part Used : ไม่ระบุActivity : CYP2E1 INDUCTIONSolvent/Active Compound : BilobalideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Bilobalide significantly induced the activity, protein, and mRNA expression of CYP3A1 and 1A2, and increased CYP 2E1 activity and CYP2B1/2 protein expression in a dose-dependent manner.Note : Data incomplete
