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Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : acetone-water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatic microsomes Results: Ginkgo biloba extract samples extracted with both acetone-water and ethanol-water showed similar induction of cytochrome P 450 in rats in vivo.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : ethanol-water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatic microsomes Results: Ginkgo biloba extract samples extracted with both acetone-water and ethanol-water showed similar induction of cytochrome P 450 in rats in vivo.Note : Data incomplete
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : standardized extract Egb 761Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg dailyDuration : 4 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : EGb 761 strongly increased liver CYP450 content.Note : Data incomplete
Part Used : -Activity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : EGB761 10 mg/kg/dayDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Propranolol*/Propanolol/Beta-propranololDose/Conc.(drug) : -Result : EquivocalRemark : CYP1A1, 1A2, 2B1/2 and 3A1 activities and gene expression in rat liver were significantly increased in a dose-dependent manner by pretreatment with EGb761.Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete
Part Used : -Activity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : EGB761 100 mg/kg/dayDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Propranolol*/Propanolol/Beta-propranololDose/Conc.(drug) : -Result : PositiveRemark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : ginkgo biloba ext. (GBE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : GBE 1,000 mg/kgDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: The content and activity of CYPs were induced markedly by a bilobalide-rich fraction, but not by flavonoid-rich fractions. The level of induction by the bilobalide-rich fraction was almost the same as that induced by the unfractionated GBE, suggesting that bilobalide is largely responsible for the CYPs induction.Note : Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : fractions of GBE (bilobalide-rich fraction)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: The content and activity of CYPs were induced markedly by a bilobalide-rich fraction, but not by flavonoid-rich fractions. The level of induction by the bilobalide-rich fraction was almost the same as that induced by the unfractionated GBE, suggesting that bilobalide is largely responsible for the CYPs induction.Note : Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : fractions of GBE (flavonoid-rich fractions)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: The content and activity of CYPs were induced markedly by a bilobalide-rich fraction, but not by flavonoid-rich fractions. The level of induction by the bilobalide-rich fraction was almost the same as that induced by the unfractionated GBE, suggesting that bilobalide is largely responsible for the CYPs induction.Note : Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : ginkgo biloba ext. (GBE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : GBE (1,000 mg/kg, contg. bilobalide at 42 mg/kg)Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Treatment with bilobalide induced CYPs markedly and in a dose-dependent manner, and the level of induction was quite similar between bilobalide (42 mg kg-1) and GBE. Treatment with GBE and with bilobalide greatly induced pentoxyresorufin O-dealkylase activity. These findings indicate that bilobalide is the major substance in GBE that induces hepatic CYPs.Note : Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : bilobalideType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : bilobalide (10.5, 21 and 42 mg/kg)Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Treatment with bilobalide induced CYPs markedly and in a dose-dependent manner, and the level of induction was quite similar between bilobalide (42 mg kg-1) and GBE. Treatment with GBE and with bilobalide greatly induced pentoxyresorufin O-dealkylase activity. These findings indicate that bilobalide is the major substance in GBE that induces hepatic CYPs.Note : Data incomplete.
