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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[1-1] of 1 article(s) found

หน้า 1 2

[1] BIOACTIVE TERPENOIDS AND FLAVONOIDS FROM GINKGO BILOBA EXTRACT INDUCE THE EXPRESSION OF HEPATIC DRUG-METABOLIZING ENZYMES THROUGH PREGNANE X RECEPTOR, CONSTITUTIVE ANDROSTANE RECEPTOR, AND ARYL HYDROCARBON RECEPTOR-MEDIATED PATHWAYS.
LI L,STANTON JD,TOLSON AH,ET AL.
PHARM RES 2009 Vol.26(4),872-82 $23607 [Full]

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : EGb 761 100 mcg/ml

Duration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with EGb 761
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : ginkgolide A (GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GA 50 microM

Duration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with GA
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : ginkgolide B (GB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GA 50 microM

Duration : Human hepatocytes cultured in William's Medium E (WME) were treated for 24 h with GB
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: In human hepatocytes, EGb 761 (100 mcg/ml), GA, and GB at 50 microM significantly induced the expressions of a series of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) target genes including CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : bilobalide (BB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : BB 50 microM

Duration : Human hepatocytes cultured in William's medium E (WME) were treated for 24 h with BB
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: In human hepatocytes, BB (50 microM), exhibited only modest effects on the expression of the tested human hepatic drug metabolizing enzymes (DMEs) and drug transporters.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : EGb 761 100 mcg/ml

Duration : Transfected cells were then treated with EGb 761 for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : quercetin (Que)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Que 25 mcg/ml

Duration : Transfected cells were then treated with Que for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : kaempferol (Kae)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Kae 20 mcg/ml

Duration : Transfected cells were then treated with Kae for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : tamarixetin (Tam)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Tam 10 mcg/ml

Duration : Transfected cells were then treated with Tam for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : ginkgolide A (GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GA 50 microM

Duration : Transfected cells were then treated with GA for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : UDP-GLUCURONYL TRANSFERASE STIMULATION

Solvent/Active Compound : ginkgolide B (GB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GB 50 microM

Duration : Transfected cells were then treated with GB for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

หน้า 1 2

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