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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[1-1] of 1 article(s) found

หน้า 1 2

[1] BIOACTIVE TERPENOIDS AND FLAVONOIDS FROM GINKGO BILOBA EXTRACT INDUCE THE EXPRESSION OF HEPATIC DRUG-METABOLIZING ENZYMES THROUGH PREGNANE X RECEPTOR, CONSTITUTIVE ANDROSTANE RECEPTOR, AND ARYL HYDROCARBON RECEPTOR-MEDIATED PATHWAYS.
LI L,STANTON JD,TOLSON AH,ET AL.
PHARM RES 2009 Vol.26(4),872-82 $23607 [Full]

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : EGb 761 100 mcg/ml

Duration : Transfected cells were then treated with EGb 761 for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids, especially Que and Kae, increased the activity of human constitutive androstane receptor (hCAR) to an extent that exceeds that of CITCO (CAR agonist) treatment in transfected HepG2 cells.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : quercetin (Que)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Que 25 mcg/ml

Duration : Transfected cells were then treated with Que for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids, especially Que and Kae, increased the activity of human constitutive androstane receptor (hCAR) to an extent that exceeds that of CITCO (CAR agonist) treatment in transfected HepG2 cells.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : Kaempferol (Kae)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Kae 20 mcg/ml

Duration : Transfected cells were then treated with Kae for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids, especially Que and Kae, increased the activity of human constitutive androstane receptor (hCAR) to an extent that exceeds that of CITCO (CAR agonist) treatment in transfected HepG2 cells.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : tamarixetin (Tam)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Tam 10 mcg/ml

Duration : Transfected cells were then treated with Tam for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids, especially Que and Kae, increased the activity of human constitutive androstane receptor (hCAR) to an extent that exceeds that of CITCO (CAR agonist) treatment in transfected HepG2 cells.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : EGb 761 100 mcg/ml

Duration : Transfected cells were then treated with EGb 761 for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761, Que, Kae, and Tam were significant activation of human constitutive androstane receptor 3 (hCAR3).

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : quercetin (Que)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Que 25 mcg/ml

Duration : Transfected cells were then treated with Que for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761, Que, Kae, and Tam were significant activation of human constitutive androstane receptor 3 (hCAR3).

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : kaempferol (Kae)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Kae 20 mcg/ml

Duration : Transfected cells were then treated with Kae for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761, Que, Kae, and Tam were significant activation of human constitutive androstane receptor 3 (hCAR3).

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : tamarixetin (Tam)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Tam 10 mcg/ml

Duration : Transfected cells were then treated with Tam for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761, Que, Kae, and Tam were significant activation of hCAR3.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : ginkgolide A (GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GA 50 microM

Duration : Transfected cells were then treated with GA for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: Transfection of CYP2B6-2.2 kb in the absence of exogenous Nuclear receptor (NRs) attest that endogenous Pregnane X receptor (PXR) and Constitutive androstane receptor (CAR) in HepG2 cells only exhibit negligible activation of the reporter compared with the potent response when exogenous PXR or CAR was included.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : RECEPTOR BINDING STIMULANT

Solvent/Active Compound : ginkgolide B (GB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GB 50 microM

Duration : Transfected cells were then treated with GB for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: Transfection of CYP2B6-2.2 kb in the absence of exogenous Nuclear receptor (NRs) attest that endogenous Pregnane X receptor (PXR) and Constitutive androstane receptor (CAR) in HepG2 cells only exhibit negligible activation of the reporter compared with the potent response when exogenous PXR or CAR was included.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

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