ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : ANTICOAGULANT ACTIVITY

Solvent/Active Compound : Ginkgo biloba special extraction (EGb 761)

Type of experiment : human

Type of animal : -

Type of study : Double-blind trial

N(Total) : 50

N(Treatment) : 50

Sex : Male

Age : 20-44 years

Route : Oral administration

Dose/Conc.(herb) : *

Duration : **

Type of interaction : Pharmacodynamics

Interaction with drug : Aspirin*/Acetylsalicylic acid/ASA/Ecosprin

Dose/Conc.(drug) : -

Result : Equivocal

Remark : Results: Acetylsalicylic acid (ASA) and the combination of ASA +EGb 761 exerted quite similar effects on all coagulation parameters measured, including bleeding time (ASA alone: 4.1 min before therapy, 6.2 min after therapy; ASA + EGb 761: 4.2 min before therapy, 6.3 min after therapy; ratio of means 1.01, 90% Cl 0.86, 1.19) and agonist - induced platelet aggregation (collagen - induced platelet aggregation - ASA: 84.5% before therapy, 81.0% after therapy; ASA + EGb 761: 86.6% before therapy, 81.0% after therapy; ratio of means: 1.00, 90% Cl 0.95, 1.05; ADP-induced platelet aggregation -ASA: 72.6% before therapy, 47.2% after therapy; ASA + EGb 761: 71.7% before therapy, 44.8% after therapy; ratio of means: 0.95, 90% Cl 0.85, 1.06).

Note : *Dose: Study medication was taken twice daily (ASA group: ASA 500 mg tablet + placebo - coated tablate in the morning and placebo tablet + placebo - coated tablet in evening; ASA + EGb 761 group: ASA 500 mg tablet + EGb 761 120 mg - coated tablet in the morning and placebo tablet + EGb 761 120 mg - coated tablet in evening. **Duration: Each treatment lasted 7 days, the washout period between treatment was 3 weeks. - Data incomplete.

---