Synonym |
Thai / English name |
Part Used : ใบActivity : NEUROPROTECTANT EFFECTSolvent/Active Compound : EGb761 (a standard form of the extract of Ginkgo biloba leaf)Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : The gerbils fed a standard diet were intragastrically given EGb761 (100 mg/kg/day) for one week and the gerbils were injected with MgSO4 (90 mg/kg), 30 min before MCAO*.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Magnesium sulfateDose/Conc.(drug) : Magnesium sulfate 90 mg/kg (MgSO4)Result : PositiveRemark : Result: The total infarct volumes of the four treated groups either EGb761 alone or in combination with drugs were lower than the control group by 36.1% (EGb761 alone), 40.3% (EGb761 + MgSO4), 35.3% (EGb761 + FK506), and 56.4% (EGb761 + MK-801), respectively (p < 0.01). The main affected areas of the brain in the four treated groups were significantly focused between 4 and 6 mm from the frontal pole, when compared to the control goups (p < 0.01). All animals in the five groups had infarctions in both cortex and subcortex. These results indicate that long-term pre-treatment of EGb761 administered either alone or in combination with drugs significantly effective neuroprotection on infarct volume in gerbil ischemic brains.Note : Type of animal: Gerbil. Rout: intragastric. *The infarct volume of male gerbils' brain induced by unilateral middle cerebral artery occlusion (MCAO).
Part Used : ใบActivity : NEUROPROTECTANT EFFECTSolvent/Active Compound : EGb761 (a standard form of the extract of Ginkgo biloba leaf)Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : The gerbils fed a standard diet were intragastrically given EGb761 (100 mg/kg/day) for one week and the gerbils were injected with FK506 (0.5 mg/kg), 30 min before MCAO*.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : TacrolimusDose/Conc.(drug) : Tacrolimus 0.5 mg/kg (FK506)Result : PositiveRemark : Result: The total infarct volumes of the four treated groups either EGb761 alone or in combination with drugs were lower than the control group by 36.1% (EGb761 alone), 40.3% (EGb761 + MgSO4), 35.3% (EGb761 + FK506), and 56.4% (EGb761 + MK-801), respectively (p < 0.01). The main affected areas of the brain in the four treated groups were significantly focused between 4 and 6 mm from the frontal pole, when compared to the control goups (p < 0.01). All animals in the five groups had infarctions in both cortex and subcortex. These results indicate that long-term pre-treatment of EGb761 administered either alone or in combination with drugs significantly effective neuroprotection on infarct volume in gerbil ischemic brains.Note : Type of animal: Gerbil. Rout: intragastric. *The infarct volume of male gerbils' brain induced by unilateral middle cerebral artery occlusion (MCAO).
Part Used : ใบActivity : NEUROPROTECTANT EFFECTSolvent/Active Compound : EGb761 (a standard form of the extract of Ginkgo biloba leaf)Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : The gerbils fed a standard diet were intragastrically given EGb761 (100 mg/kg/day) for one week and the gerbils were injected with MK-801 (1 mg/kg), 30 min before MCAO*.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : DizocilpineDose/Conc.(drug) : Dizocilpine 1 mg/kg (MK-801)Result : PositiveRemark : Result: The total infarct volumes of the four treated groups either EGb761 alone or in combination with drugs were lower than the control group by 36.1% (EGb761 alone), 40.3% (EGb761 + MgSO4), 35.3% (EGb761 + FK506), and 56.4% (EGb761 + MK-801), respectively (p < 0.01). The main affected areas of the brain in the four treated groups were significantly focused between 4 and 6 mm from the frontal pole, when compared to the control goups (p < 0.01). All animals in the five groups had infarctions in both cortex and subcortex. These results indicate that long-term pre-treatment of EGb761 administered either alone or in combination with drugs significantly effective neuroprotection on infarct volume in gerbil ischemic brains.Note : Type of animal: Gerbil. Rout: intragastric. *The infarct volume of male gerbils' brain induced by unilateral middle cerebral artery occlusion (MCAO).