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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginkgolide B (GB)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 10 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Probenecid*/BenemidDose/Conc.(drug) : 300 mg/kgResult : PositiveRemark : The systemic exposure in the group treated with probenecid (p<0.05 vs control) was significantly raised to 14.75+/-1.328 microgram/mL/h. Specifically, probenecid could significantly decreased the CLtotal of GB from 1.17+/-0.331 to 0.596+/-0.0573 L/h/kg. Albeit probenecid could significantly reduce GB clearance and volume of distribution (V) when compared with control group, the elimination half-time (t1/2lambda) of each group remained close to each other, fitted as 2.04+/-0.376, and 2.34+/-0.851, for the control and probenecid, respectively.Note : CLtotal = total plasma clearance
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Ginkgolide B (GB)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 10 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Probenecid*/BenemidDose/Conc.(drug) : 300 mg/kgResult : PositiveRemark : The systemic exposure in the group treated with probenecid (p<0.05 vs control) was significantly raised to 14.75+/-1.328 microgram/mL/h. Specifically, probenecid could significantly decreased the CLtotal of GB from 1.17+/-0.331 to 0.596+/-0.0573 L/h/kg. Albeit probenecid could significantly reduce GB clearance and volume of distribution (V) when compared with control group, the elimination half-time (t1/2lambda) of each group remained close to each other, fitted as 2.04+/-0.376, and 2.34+/-0.851, for the control and probenecid, respectively.Note : CLtotal = total plasma clearance
Part Used : ไม่ระบุActivity : OATP (ORGANIC ANION TRANSPORTER PROTEIN) INHIBITIONSolvent/Active Compound : Ginkgolide B (GB)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 10 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Probenecid*/BenemidDose/Conc.(drug) : 300 mg/kgResult : PositiveRemark : Without the presence of inhibitors, the accumulative excretion of GB was calculated at around 962.2 microgram. Without the presence of inhibitors, the accumulative excretion of GB was calculated at around 962.2 microgram, while the excretion was significantly decreased to 370.3 microgram when pretreated with probenecid (potential inhibitor of organic anion transporter/organic anion transporting polypeptides). The probenecid could exert obvious and strong inhibition from the very beginning afer dosing.Note : CLtotal = total plasma clearance
