ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : DRUG INTERACTION

Solvent/Active Compound : Natural standardized extraction of Ginkgo biloba leaves (Gin, Egb 761)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : *

Duration : 2 weeks

Type of interaction : Pharmacodynamics

Interaction with drug : Aprotinin

Dose/Conc.(drug) : -

Result : Positive

Remark : Aprotinin alone significantly reduced the venom-elicited increase in glucose-6-phosphate dehydrogenase and lactate dehydrogenase activities and decrease in glutathione peroxidase levels (p<0.05). In general, these protective effects of EGb 761 on reduced glutathione, malondialdehyde (p<0.01 vs. venom) and lactate dehydrogenase (p< 0.001) in the heart/or lung were potentiated when combined with aprotinin.

Note : * Rats were treated with leiurus quinquestriatus (LQQ) venom (0.3 mg/kg, s.c.) alone or after Gin (150 mk/kg, orally, daily for 2 weeks before venom) and/or aprotinin (Apr, 46000 KIU/kg, i.p., 30 min before venom). Control groups were injected with saline or treatment modalities. - Data incomplete.

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