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Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 8N(Treatment) : 8Sex : MaleAge : 24-45 (29+/-3 years)Route : Oral administrationDose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)Duration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : NegativeRemark : Simultaneous oral ingestion of GBE (240 mg) did not significantly affect any of the mean pharmacokinetic parameters of either nifedipine (NFP) or dehydronifedipine, a major metabolite of NEP, after oral administration of NFP (10 mg). However, the maximal plasma NFP concentrations in 2 subjects were approximately doubled by GBE.Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 8N(Treatment) : 8Sex : MaleAge : 24-45 (29+/-3 years)Route : Oral administrationDose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)Duration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : NegativeRemark : Simultaneous oral ingestion of GBE (240 mg) did not significantly affect any of the mean pharmacokinetic parameters of either nifedipine (NFP) or dehydronifedipine, a major metabolite of NEP, after oral administration of NFP (10 mg). However, the maximal plasma NFP concentrations in 2 subjects were approximately doubled by GBE.Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
Part Used : ใบActivity : CARDIOVASCULAR EFFECTS(UNSPECIFIED)Solvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 8 (M/F=8/-)N(Treatment) : 8 (M/F=8/-)Sex : MaleAge : 24-45 (29+/-3 years)Route : Oral administrationDose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)Duration : 2 weeksType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : 2 subjects were approximately doubled by GBE, and they had severer and longer-lasting headaches with GBE than without GBE, with dizziness or hot flushes in combination with GBE. The mean heart rate after oral administration of NFP with GBE tended to be faster than that without GBE at every time point.Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
Part Used : ใบActivity : ALGESIC ACTIVITYSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 8 (M/F=8/-)N(Treatment) : 8 (M/F=8/-)Sex : MaleAge : 24-45 (29+/-3 years)Route : Oral administrationDose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)Duration : 2 weeksType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : 2 subjects were approximately doubled by GBE, and they had severer and longer-lasting headaches with GBE than without GBE, with dizziness or hot flushes in combination with GBE. The mean heart rate after oral administration of NFP with GBE tended to be faster than that without GBE at every time point.Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
Part Used : ใบActivity : HYPOTENSIVE ACTIVITYSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 8 (M/F=8/-)N(Treatment) : 8 (M/F=8/-)Sex : MaleAge : 24-45 (29+/-3 years)Route : Oral administrationDose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)Duration : 2 weeksType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : NegativeRemark : The systolic and diastolic pressures before and after oral administration of NFP with and without GBE. The stable systolic pressures before the NFP administration were 124+/-4 and 124+/-4 mmHg, and the diastolic pressures were 79+/-3 and 74+/-3 mmHg in the control and GBE groups, respectively. In the control group, the mean systolic pressure decreased maximally by about 9% at 2 h and the mean diastolic pressure decreased by about 16% at 1 h after drug administration; they were almost normalized after 8 h in both groups. However, no significant differences in their values at any time point between the two groups were observed.Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginkgo flavonoidsType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat hepatic microsome Results: Nifedipine, propafenone and ipriflavone inhibit the metabolism of Ginkgo flavonoids (quercetin, isorhamnetin and kaempferol) at different levels.Note : Data incomplete
