Synonym |
Thai / English name |
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Ginkgo extracts: 4.78% Quercetin, 3.73% Kaempferol, 2.13% Isorhamnetin, 12.0% Quercetin glycoside, 9.65% Kaempferol glycoside, 5.19% Isorhamnetin glycoside, 1.61% Bilobalide, 1.41 Ginkgolide A, 0.31% Ginkgolide J, 5.57% Ginkgolide B, 0.38% Ginkgolide C. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 45.1% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 155 microgram/ml, 95% Cl: 81.3-297.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Ginkgo extracts: 4.78% Quercetin, 3.73% Kaempferol, 2.13% Isorhamnetin, 12.0% Quercetin glycoside, 9.65% Kaempferol glycoside, 5.19% Isorhamnetin glycoside, 1.61% Bilobalide, 1.41 Ginkgolide A, 0.31% Ginkgolide J, 5.57% Ginkgolide B, 0.38% Ginkgolide C. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 45.1% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 155 microgram/ml, 95% Cl: 81.3-297.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).