Part Used : ผล
Activity : CYP2E1 INHIBITION
Solvent/Active Compound : Aqueous
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 4-4000 microgram/ml
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Fennel tea fully inhitbited CYP2E1 activity in vitro with IC50 23+/-4 microgram/ml. The data suggest that fennel has a significant potential of inhibiting all the major metabolic pathways for acetaminophen oxidation and N-acetyl-p-benzoquinone imine formation.