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Part Used : เปลือกต้นActivity : MULTIDRUG RESISTANCE INHIBITIONSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlitreDuration : 20 hoursType of interaction : PharmacodynamicsInteraction with drug : MeropenemDose/Conc.(drug) : 25 microlitreResult : NegativeRemark : - MIC of one sample alone for meropenem (microgram/ml) = 4, for cinnamon bark (%, v/v) = 0.039 - MIC of one sample of the most effective combination for meropenem (microgram/ml) = 1, for cinnamon bark (%, v/v) = 0.020 - FIC of antibiotic = 0.25 - FIC of oil = 0.50 - FICI = 1.75Note : The miniumum inhibitory concentration (MIC) values of the bacterial strains under study were determined by means or broth microdilution as stated in CLSI M07-A8. FIC = fraction inhibitory concentration. FICI = the combined effects of the antibiotics and essential oils were calculated and expressed in terms of FIC (FICI 0.5-4.0, no interaction; FICI > 4.0 antagonism).
Part Used : เปลือกต้นActivity : DRUG INTERACTIONSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlitreDuration : 20 hoursType of interaction : PharmacodynamicsInteraction with drug : MeropenemDose/Conc.(drug) : 25 microlitreResult : NegativeRemark : - MIC of one sample alone for meropenem (microgram/ml) = 4, for cinnamon bark (%, v/v) = 0.039 - MIC of one sample of the most effective combination for meropenem (microgram/ml) = 1, for cinnamon bark (%, v/v) = 0.020 - FIC of antibiotic = 0.25 - FIC of oil = 0.50 - FICI = 1.75Note : The miniumum inhibitory concentration (MIC) values of the bacterial strains under study were determined by means or broth microdilution as stated in CLSI M07-A8. FIC = fraction inhibitory concentration. FICI = the combined effects of the antibiotics and essential oils were calculated and expressed in terms of FIC (FICI 0.5-4.0, no interaction; FICI > 4.0 antagonism).
Part Used : เปลือกต้นActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlitreDuration : 20 hoursType of interaction : PharmacodynamicsInteraction with drug : MeropenemDose/Conc.(drug) : 25 microlitreResult : NegativeRemark : - MIC of one sample alone for meropenem (microgram/ml) = 4, for cinnamon bark (%, v/v) = 0.039 - MIC of one sample of the most effective combination for meropenem (microgram/ml) = 1, for cinnamon bark (%, v/v) = 0.020 - FIC of antibiotic = 0.25 - FIC of oil = 0.50 - FICI = 1.75Note : The miniumum inhibitory concentration (MIC) values of the bacterial strains under study were determined by means or broth microdilution as stated in CLSI M07-A8. FIC = fraction inhibitory concentration. FICI = the combined effects of the antibiotics and essential oils were calculated and expressed in terms of FIC (FICI 0.5-4.0, no interaction; FICI > 4.0 antagonism).
