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Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : Cinnamic acid

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 0-100 micromolar

Duration : 24-48 hours

Type of interaction : Pharmacodynamics

Interaction with drug : Thiazolidinedione*/2,4-thiazolidinedione

Dose/Conc.(drug) : 0-100 micromolar

Result : Equivocal

Remark : - Thiazolidinedione (20 micromolar) in combination with ferulic acid (25 micromolar), eugenol (50 micromolar), chlorogenic acid (25 micromolar), caffeic acid (25 micromolar), and p-coumaric acid (25 micromolar) increased 2DG uptake by 7-, 6.8-, 6.7-, 6.5-, and 6.34-fold, respectively, with respect to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.

Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.

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