Part Used : เปลือกต้น
Activity : CYP2E1 INHIBITION
Solvent/Active Compound : o-methoxycinnamaldehyde
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Non-specified
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : The component inhibiting drug oxidation catalyzed by CYP1A2 and CYP2E1 was isolated from cinnamomi cortex, and was identified as o-methoxycinnamaldehyde (OMCA). The OMCA was shown to be competitive inhibitor against CYP1A2 while it was a mixed type inhibitor against CYP2E1. The inhibitory effect of OMCA on 4-nitrophenol 2-hydroxylation (Ki=6.3 micromolar) was somewhat potent compared to that observed on phenacetin O-deethylation (Ki=13.7 micromolar) in rat liver microsomes.