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Part Used : เปลือกต้น

Activity : CYP1A2 INHIBITION

Solvent/Active Compound : o-methoxycinnamaldehyde

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Non-specified

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The component inhibiting drug oxidation catalyzed by CYP1A2 and CYP2E1 was isolated from cinnamomi cortex, and was identified as o-methoxycinnamaldehyde (OMCA). The OMCA was shown to be competitive inhibitor against CYP1A2 while it was a mixed type inhibitor against CYP2E1. The inhibitory effect of OMCA on 4-nitrophenol 2-hydroxylation (Ki=6.3 micromolar) was somewhat potent compared to that observed on phenacetin O-deethylation (Ki=13.7 micromolar) in rat liver microsomes.

Note : Data incomplete

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