ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Ketoconazole*/Nizoral/Levoketoconazole/Panfungol/Ketoisdin/Orifungal M/Ketozole/Normocort/Ketoderm/Fungarest/Fungoral/Extina/Ketoconazolum/Brizoral/Kuric/Ketoconazol/Xolegel/Onofin K/Teryzolin/Terzolin

Dose/Conc.(drug) : -

Result : Positive

Remark : The IC50/IC25 ratios for the inhibiting herbal remedies ranged from 2.15 to 2.67, indicating similar inhibition profiles of the herbal inhibitors of CYP3A4. Garlic and Natto K2 were classified as non-inhibitors. Although Agaricus, noni juice, mistletoe and green tea inhibited CYP3A4 metabolism in vitro, clinically relevant systemic or intestinal interactions with CYP3A4 were considered unlikely, except for a probable inhibition of intestinal CYP3A4 by the green tea product.

Note : Testosterone was used as a substrate and ketoconazole as a positive quantitative inhibition control.

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