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| Thai / English name |
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml of onion extract containing 1.14 g of onion extract as low doseDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.5 ml of onion extract containing 1.7 g of onion extract as high doseDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml of onion extract containing 1.14 g of onion extract as low dose + potassium iodine solutionDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.5 ml of onion extract containing 1.7 g of onion extract as high dose + potassium iodine solutionDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : quercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.Note : Data from review
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : quercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.Note : Data from review
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 46N(Treatment) : 23Sex : FemaleAge : 30-65 yrs.Route : Oral administrationDose/Conc.(herb) : BMI < 24.9 cosumed fresh onion 100-120 g/day, BMI > 25 cosumed fresh onion 140-160 g/dayDuration : 8 weeksType of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : The effectiveness of onion to control CEA and CA125 tumor markers. But they were not significant between groups at the end of study among BC patients during doxorubicin (DOX) based chemotherapy. Manipulation of diet through high intake of onion is promising to possibly improve a synergistic effect on DOX-based chemotherapy.Note : Patients were breast cancer (BC) participants treated with doxorubicin
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 46N(Treatment) : 23Sex : FemaleAge : 30-65 yrs.Route : Oral administrationDose/Conc.(herb) : fresh onion 30-40 g/day (control)Duration : 8 weeksType of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : The effectiveness of onion to control CEA and CA125 tumor markers. But they were not significant between groups at the end of study among BC patients during doxorubicin (DOX) based chemotherapy. Manipulation of diet through high intake of onion is promising to possibly improve a synergistic effect on DOX-based chemotherapy.Note : Patients were breast cancer (BC) participants treated with doxorubicin
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark :Note : - Cyclosporin was administered orally and i.v. to rats with and without an oral dose of ginkgo or onion in crossover designs. - Oral coadministration of ginkgo and onion significantly decreased the Cmax of cyclosporine by 62% and 60%, and reduced the AUC0-t by 51% and 68%, respectively, whereas no influence observed when cyclosporine was given by i.v. - Data incomplete.
