ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

AMARYLLIDACEAE Allium cepa L. cv.group cepa

Synonym

ALLIACEAE Porrum cepa Rchb.

Thai / English name

หอมหัวใหญ่*

[1-2] of 2 article(s) found

หน้า 1

[1] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : ใบ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : quercetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.

Note : Data from review

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : quercetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.

Note : Data from review

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : quercetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.

Note : Data from review

Part Used : หัว
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : quercetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Quercetin could enhance the anticancer activity of doxorubicin against multidrug resistant MCF-7 breast carcinoma by inhibiting the expression and activity of p-glycoprotein at a very low concentration of 0.7 micromolar.

Note : Data from review

[2] EFFECTS OF FRESH YELLOW ONION CONSUMPTION ON CEA, CA125 AND HEPATIC ENZYMES IN BREAST CANCER PATIENTS: A DOUBLE- BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL.
FARNAZ JAFARPOUR-SADEGH,VAHID MONTAZERI,ALI ADILI,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(17),7517-22 $60686 [Full]

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Double-blind trial

N(Total) : 46
N(Treatment) : 23

Sex : Female
Age : 30-65 yrs.

Route : Oral administration
Dose/Conc.(herb) : BMI < 24.9 cosumed fresh onion 100-120 g/day, BMI > 25 cosumed fresh onion 140-160 g/day

Duration : 8 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : The effectiveness of onion to control CEA and CA125 tumor markers. But they were not significant between groups at the end of study among BC patients during doxorubicin (DOX) based chemotherapy. Manipulation of diet through high intake of onion is promising to possibly improve a synergistic effect on DOX-based chemotherapy.

Note : Patients were breast cancer (BC) participants treated with doxorubicin

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Double-blind trial

N(Total) : 46
N(Treatment) : 23

Sex : Female
Age : 30-65 yrs.

Route : Oral administration
Dose/Conc.(herb) : fresh onion 30-40 g/day (control)

Duration : 8 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : The effectiveness of onion to control CEA and CA125 tumor markers. But they were not significant between groups at the end of study among BC patients during doxorubicin (DOX) based chemotherapy. Manipulation of diet through high intake of onion is promising to possibly improve a synergistic effect on DOX-based chemotherapy.

Note : Patients were breast cancer (BC) participants treated with doxorubicin

หน้า 1

EN

Web Link ที่เกี่ยวข้อง

ที่อยู่