Synonym |
Thai / English name |
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark :Note : - Cyclosporin was administered orally and i.v. to rats with and without an oral dose of ginkgo or onion in crossover designs. - Oral coadministration of ginkgo and onion significantly decreased the Cmax of cyclosporine by 62% and 60%, and reduced the AUC0-t by 51% and 68%, respectively, whereas no influence observed when cyclosporine was given by i.v. - Data incomplete.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark :Note : - Cyclosporin was administered orally and i.v. to rats with and without an oral dose of ginkgo or onion in crossover designs. - Oral coadministration of ginkgo and onion significantly decreased the Cmax of cyclosporine by 62% and 60%, and reduced the AUC0-t by 51% and 68%, respectively, whereas no influence observed when cyclosporine was given by i.v. - Data incomplete.