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Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : Aqueous extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were 753.2 microgram/mL.Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : methanol extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were 155.2 microgram/mL.Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : dichloromethane extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were 160.8 microgram/mL.Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : Petroleum ether extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were 221.9 microgram/mL.Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : rosmarinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were 114.9 microgram/mL. (318.9 micromolar)Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : sinensetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were >200 microgram/mL. (>537.1 micromolar)Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
Part Used : ทั้งต้นActivity : CYP2C9 INHIBITIONSolvent/Active Compound : eupatorinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : IC50 values for inhibition of CYP2C9 were >200 microgram/mL. (>580.9 micromolar)Note : - Orthosiphon stamineus (OS) components with IC50 values less than 100 microgram/mL (100 micromolar for active constituents) were subsequently determined for Ki (inhibition constant) values and inhibition modes. - In order to determine the modulatory effects of OS components on CYP activities, the enzyme assays were carried out in the presence and absence of OS extracts or active constituents. Metabolite (4-hydroxytolutamide, dextrophan and 6beta-hydroxytestosterone) formations were estimated using HPLC system. For each inhibition study, preliminary experiments were carried out by incubating a single enzyme specific substrate concentration around its Km with a range of OS extract and active constiuent concentrations to determine IC50 values (concentration on inhibitor causing 50% inhibition of enzyme activity).
