ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : petroleum ether extract

Type of experiment : in vitro

Type of animal : other

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Andrographis paniculata (AP) ethanol extract and Centella asiatica (CA) dichloromethane extract exhibited mixed type inhibition towards CYP2C19 with Ki values of 67.1 and 16.4 microgram/ml respectively; CA ethanol extract and Orthosiphon stamineus (OS) petroleum ether extract competitively CYP2C19 activity (Ki =39.6 and 41.5 microgram/ml respectively). Eupatorin (a major active constituent of OS) was found to significantly inhibit CYP2C19 by mixed type inhibition (Ki=7.1 microgram/ml or 20.6 micromolar

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