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Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ethanol extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 7 days (see note)Type of interaction : PharmacokineticsInteraction with drug : IrbesartanDose/Conc.(drug) : 40 mg/kgResult : PositiveRemark : The plasma concentration of irbesartan and half time in the group combination of irbesartan and extract of O. stamineus was higher and longer than the group irbesartan alone.Note : Type of experiment: The rats were given 500 mg/kg body weight of ethanol extract of O. stamineus orally for six days and on the 7th day were given 40 mg/kg body weight of iresartan orally concomitant with extract.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : ethanol extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 7 days (see note)Type of interaction : PharmacokineticsInteraction with drug : IrbesartanDose/Conc.(drug) : 40 mg/kgResult : PositiveRemark : The plasma concentration of irbesartan and half time in the group combination of irbesartan and extract of O. stamineus was higher and longer than the group irbesartan alone.Note : Type of experiment: The rats were given 500 mg/kg body weight of ethanol extract of O. stamineus orally for six days and on the 7th day were given 40 mg/kg body weight of iresartan orally concomitant with extract.