ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : CYTOCHROME P-450 1A1 MONOOXYGENASE INHIBITION

Solvent/Active Compound : red ginseng saponins (ginsenosides-Rb1, -Rb2, -Rc, -Rd, -Re, -Rg1

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : Total saponin 0-1,250 mcg/ml

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: rat liver microsomes Result: The standardized saponin of red ginseng showed inhibitory effect on P450-associated monooxygenase activities in a dose-dependent manner in rat liver microsomes. When the total saponin was added into the reaction mixtures for assaying different kind of P450 isozyme-selective monooxygenase, the activities of EROD (P450 1A1-selective), BROD (2B1), ERDM (3A1), and APDM (relatively broader spectrum of isozyme selectivity) were clearly inhibited in rat liver microsomes. Meanwhile neither P450 1A2-selective MROD nor electron-transferring NADPH-P450 reductase (Reductase) were inhibited by the addition of total saponin.

Note : Liver microsomes were isolated from untreated rats.

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