Part Used : ราก
Activity : PHARMACOKINETIC ALTERATION
Solvent/Active Compound : Panax ginseng (PGS) water extract
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : PGS extract 0.81 g/kg, twice daily
Duration : ten consecutive days
Type of interaction : Pharmacokinetics
Interaction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FU
Dose/Conc.(drug) : -
Remark : Result: The time to reach the maximum concentration (Tmax) was 14.56 min in the PGS pretreated groups, and 10.37 min in the control gruop. After pretreatment with PGS, the elimination half-life of 5-FU was significantly increased from 79.17 to 125.72, which was an increase of approximately 58.8% compared with the control. The results indicate that PGS may affect the elimination of 5-FU.