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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : GinsenosidesType of experiment : humanType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data incomplete, data from review article.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PG) suspensionType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : gastric gavage feeding of PG suspension 150 mg/kg/dayDuration : 14 consecutive daysType of interaction : PharmacokineticsInteraction with drug : FexofenadineDose/Conc.(drug) : -Result : PositiveRemark : A single dose of fexofenadine (100 mg/kg for oral dose) was administered after 14 days of feeding PGS. Blood samples were collected from 0 to 12 h. and levels of fexofenadine were measured by LC-MS/MS. Result: PG deoreased the AUC between 0-12h, decreased Cmax, and decreased ratios of brain to plasma concentration. The mean bioavailability of fexofenadine was decreased by 16.1%.Note : Long term administration of Panax ginseng to rats might induce both intestinal and brain endothelium p-glycoprotein expression. In addition, long term use of Panax ginseng reduced the bioavailability of concurrently administered fexofenadine.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PG) suspensionType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : gastric gavage feeding of PG suspension 150 mg/kg/dayDuration : 14 consecutive daysType of interaction : PharmacokineticsInteraction with drug : FexofenadineDose/Conc.(drug) : -Result : PositiveRemark : A single dose of fexofenadine (10 mg/kg for intravenous) was administered after 14 days of feeding PGS. Blood samples were collected from 0 to 2 h. and levels of fexfenadine were measured by LC-MS/MS. Result: PG reduced ratios of brain to plasma concentration.Note : Long term administration of Panax ginseng to rats might induce both intestinal and brain endothelium p-glycoprotein expression. In addition, long term use of Panax ginseng reduced the bioavailability of concurrently administered fexofenadine.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The time to reach the maximum concentration (Tmax) was 14.56 min in the PGS pretreated groups, and 10.37 min in the control gruop. After pretreatment with PGS, the elimination half-life of 5-FU was significantly increased from 79.17 to 125.72, which was an increase of approximately 58.8% compared with the control. The results indicate that PGS may affect the elimination of 5-FU.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : BST204Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : **Type of interaction : Non-specifiedInteraction with drug : Irinotecan*/Camptothecin-11/CPT-11Dose/Conc.(drug) : -Result : NegativeRemark : - BST204 and irinotecan co-administration. Thirty mimutes prior to irinotecan administration, BST204 (suspended in distilled water) at a dose of 400 mg (in 10mL)/kg was orally administered. Then, Irinotecan (dissolved in DMSO: 0.9% NaCl injectable solution, v/v = 5:95) at a dose of 20 mg (in 3 mL)/ kg was intraperitoneally administered to rats. ** Blood from each rat (approximately 0.12 mL) was collected in a chilled Eppendorf tube at 0, 5, 15, 30, 60, 90, 120, 180, 240, 360, 480, and 600 min after irinotecan administration.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : BST204 (a purified dry extract of ginseng)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Irinotecan*/Camptothecin-11/CPT-11Dose/Conc.(drug) : -Result : NegativeRemark : Irinotecan 20 mg/kg (intraperitoneal administration).
