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Part Used : -Activity : CYP1A4 INHIBITIONSolvent/Active Compound : Ginsenoside R-Rg3Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-50 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 micromolar.