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| Thai / English name |
Part Used : -Activity : CYP3A4/5 INHIBITIONSolvent/Active Compound : Ginsenoside S-Rg3Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-50 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 micromolar.
Part Used : -Activity : CYP3A4/5 INHIBITIONSolvent/Active Compound : Ginsenoside R-Rh2Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-50 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 micromolar.
Part Used : -Activity : CYP3A4/5 INHIBITIONSolvent/Active Compound : Ginsenoside S-Rh2Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-50 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and S-Rh2 weakly inhibited CYP2B6 and CYP3A4/5 activities, with IC50 values of 24.2 and 43.5 micromolar, respectively.
Part Used : -Activity : CYP3A4/5 INHIBITIONSolvent/Active Compound : BST204 (a purified dry extract of gineseng)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-50 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of BST 204 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2C19, CYP2E1, and CYP3A4/5) was > 50 micromolar.
Part Used : รากActivity : CYP3A4/5 INHIBITIONSolvent/Active Compound : 20(S)-ginsenoside F1 (20(S)-GF1), ginsenoside Rh1(Rh1)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Human liver microsomes Result: 18 beta-GA, DAG, 20(S)-GF1 and Rh1 significantly inhibited CYP3A activity (44, 41, 23 and 15% inhibition, respectively)
