Part Used : ไม่ระบุ
Activity : CYP3A INHIBITION
Solvent/Active Compound : ginsenosides
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : The concentrations of 20(S)-protopanaxadiol derivatives Rb1, Rb2, Rc, C-K and 20(S)-protopanaxatriol derivatives Re, Rg1, Rg2, Pt and Ppt were 500 micromolars, 500 micromolars, 250 micromolars, 500 micromolars, 500 micromolars, 500 micromolars, 100 micromolars, 500 micromolars, and 500 micromolars
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Result: Ginsenosides from the 20(S)-protopanaxadiol and 20(S)-protopanaxatriol family including Rb1, Rb2, Rc, compound-K, Re, and Rg1 had no inhibitory effect, whereas Rg2, 20(S)-panaxatriol and 20(S)-protopanaxatriol exhibited competitive inhibitory activity against CYP3A activity in these microsomes with the inhibition constants (Ki) of 86.4+/-0.8 micromolars, 1.7 +/-0.1 micromolars, and 3.2 +/-0.2 micromolars, respectively.
Note : Type of experiment: rat liver microsomes