ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : CYP2C9 INHIBITION

Solvent/Active Compound : BST204

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine - CYP isozyme cocktail assay in pooled human liver microsomes. Combining nine specific substrates for each CYP in cocktails is particularly useful because it is possible to measure multiple CYP activities in the same microsomal incubation. In brief, the 90-microlitre incubation mixture, including pooled human liver microsomes (final concentration 0.25 mg/mL), 0.1 M phosphate buffer, each P450-selective substrate cocktail set, and test compounds (0-5 micromolars) was pre-incubated for 5 min at 37 degrees celsius.

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