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ARALIACEAE Panax ginseng C.A. Mey.

Synonym

none ...

Thai / English name

โสม*

[1-2] of 2 article(s) found

หน้า 1 2

[1] EFFECTS OF SUPERFINE GRINDING ON PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF LYCIUM BARBARUM POLYSACCHARIDES.
MIN ZHANG,FANG WANG,RUI LIU,ET AL.
LWT - FOOD SCIENCE AND TECHNOLOGY 2014 Vol.58(),594-601 $50580 [Full]

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : BST204

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine - CYP isozyme cocktail assay in pooled human liver microsomes. Combining nine specific substrates for each CYP in cocktails is particularly useful because it is possible to measure multiple CYP activities in the same microsomal incubation. In brief, the 90-microlitre incubation mixture, including pooled human liver microsomes (final concentration 0.25 mg/mL), 0.1 M phosphate buffer, each P450-selective substrate cocktail set, and test compounds (0-5 micromolars) was pre-incubated for 5 min at 37 degrees celsius.

[2] EVALUATION OF THE IN VITRO/IN VIVO DRUG INTERACTION POTENTIAL OF BST204, A PURIFIED DRY EXTRACT OF GINSENG, AND ITS FOUR BIOACTIVE GINSENOSIDES THROUGH CYTOCHROME P450 INHIBITION/INDUCTION AND UDP-GLUCURONOSYLTRANSFERASE INHIBITION.
YU FEN ZHENG,SOO HYEON BAE,EU JIN CHOI,ET AL.
FOOD CHEM TOXICOL 2014 Vol.68(),117-27 $50850 [Full]

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.00 +/- 0.0588, 0.984 +/- 0.113 and 0.922 +/- 0.109, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.01 +/- 0.188, 0.975 +/- 0.0915 and 0.856 +/- 0.148, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each each CYP were 1.08 +/- 0.148, 0.940 +/- 0.198 and 0.976 +/- 0.190, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.0311, 1.11 +/- 0.212, and 0.988 +/- 0.0181, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.0618, 1.13 +/- 0.0754, and 0.979 +/- 0.00715, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.940 +/- 0.0522, 1.08 +/- 0.150, and 0.979 +/- 0.0980, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.989 +/- 0.112, 1.03 +/- 0.164, and 0.872 +/- 0.0500, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.989 +/- 0.0884, 1.04 +/- 0.144, and 0.849 +/- 0.0706, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.09 +/- 0.0739, 1.03 +/- 0.0516, and 0.846 +/- 0.0438, respectively.

หน้า 1 2

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