Part Used : ไม่ระบุ
Activity : CYP2E1 INDUCTION
Solvent/Active Compound : ginsenoside Rh1
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 10-100 micromolars of Rh1
Duration : 10 min incubation
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Result: Rh1 exhibited a weak stimulation rather than an inhibition of the activity of CYP2E1.
Note : Type of experiment: Human livers were obtained from three Chinese autopsy sample (males, ages 27, 29 and 42 years).
Conclusion: The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh1 and F1.