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Part Used : รากActivity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : 20(S)-protopanaxatriol (ppt)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : ppt 100 mMDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 mM for UGT1A1 and UGT2B7, respectively. Using the maximum plasma concentration of ppt, the alteration of area under the concentration-time curve as calculated to be 20% and 70% respectively for UGT1A1-mediated and UGT2B7-mediated metabolism.Note : Due to the lack of specific substrates for various UGT isoforms, the nonspecific probe substrate 4-MU and recombinant UGT enzymes were brought to bear on the present study.
Part Used : -Activity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : BST24 (a purified dry extract of ginseng)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : BST204 weakly inhibited UGT1A1, UGT1A9, and UGT2B7 activities with IC50 values of 14.5, 26.6, and 31.5 microgram/mL, respectively.
Part Used : -Activity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : Ginsenoside S-Rg3Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Ginsenoside S-Rg3 inhibited UGT1A1, UGT1A9, and UGT2B7 activities, with IC50 values of 89.0, 14.9, 21.5 micromolar, respectively.
Part Used : -Activity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : Ginsenoside R-Rg3Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark :
Part Used : -Activity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : Ginsenoside S-Rh2Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Ginsenoside S-Rh2 inhibited UGT1A1 activities, with IC50 values of 54.5 micromolar.
Part Used : -Activity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : Ginsenoside R-Rh2Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark :
