Part Used : ราก
Activity : HEPATOTOXIC ACTIVITY
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Case report
N(Total) : 1
N(Treatment) : 1
Route : Oral administration
Dose/Conc.(herb) : Daily ingestion of Panax ginseng via energy drinks
Duration : 3 months
Type of interaction : Pharmacodynamics
Interaction with drug : Imatinib*/Glivec/Imatinib mesylate
Dose/Conc.(drug) : 400 mg daily
Note : A 26-year-old man with chronic myelogenous leukemia who had taken imatinib 400 mg daily for 7 years with no complications presented with right upper quadrant pain. Laboratory test results included alanine aminotransferase 1069 U/L, aspartate aminotransferase 481 U/L, alkaline phosphatase 124 IU/L, total bilirubin 1.4 mg/dL, albumin 4.0 g/dL, and international normalized ratio 1.08. Liver biopsy showed acute lobular hepatitis favoring a drug-induced etiology, and a diagnosis of imatinib-induced hepatotoxicity was made. The patient's only lifestyle modification prior to the diagnosis of hepatotoxicity was daily ingestion of Panax ginseng via energy drinks for the past 3 months. Both imatinib and ginseng were discontinued, and the patient was treated with a short course of corticosteroids. Imatinib was later restarted at the same dose with no recurrent elevations in his liver enzyme levels. They propose that the patien's late-onset imatinib-associated hepatotoxicity was due to an interaction between ginseng and imatinib through CYP3A4.
