ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : TUMOR PROMOTION INHIBITION

Solvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Intraperitoneal

Dose/Conc.(herb) : 20 mg/kg Rg3, in phosphate-buffed saline

Duration : 21 days

Type of interaction : Pharmacodynamics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria

Dose/Conc.(drug) : 1 mg/kg, 3 times/weks

Result : Positive

Remark : Rg3 or doxorubicin treatment alone had minimal effect on the growth of tumors at the doses used, with the tumor size similar to the control mice. Notably, combined treatment with Rg3 and doxorubicin led to significant reduction of the tumor volume on xenograft model mouse. Consistent with the data on tumor volume, the tumor weight was also significantly decreased in combination of Rg3 and doxorubicin. The tumors from mice treated with the Rg3-doxorubicin combination showed that the cell density was greatly lower than in the Rg3-or doxorubicin-only groups. Type of animal: Male, 6-week-old nude mice.

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