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Part Used : รากActivity : CYTOTOXIC ACTIVITYSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The combination of 5-FU and PGS did not show a synergistic inhibitory effect on three different cancer lines (A549, BIU-87 and SW480). The results indicate that the observed cytotoxicity was primarily generated by 5-FU alone. But the combination of 5-FU and PGS showed a synergistic inhibitory effect on BGC823 (human gastric cancer cell line) but not on GES-1 (human normal gastric epithelial cell line).
Part Used : รากActivity : CYTOTOXIC ACTIVITYSolvent/Active Compound : waterType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imatinib*/Glivec/Imatinib mesylateDose/Conc.(drug) : 0.1 micromolarResult : PositiveRemark : Treated KBM-5, K562, THP-1, U266, and MM1.S cells with KRGE in combination with IM for 24 h, and then examined the cell viability with an MTT assay. The results found that KRGE indeed enhanced the cytotoxic effects of IM only in KBM-5 cells. The combination treatment indeed enhanced apoptosis by activation of caspase-3 and induced PARP cleavage, suppressed antiapoptosis and proliferative proteins expression, decreased the phosphorylation of p38, STAT5, and p53 in KBM-5 cells and inhibited STAT5-DNA binding activities. These results show that KRGE and IM can abrogate the DNA binding ability of STAT5.Note : Imatinib mesylate = IM
Part Used : ไม่ระบุActivity : CYTOTOXIC ACTIVITYSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 micromolarDuration : lncubation for 30 minType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 2.5 micromolarResult : PositiveRemark : Rg3 is able to sensitize hepatocellular carcinoma cell (HCC) to doxorbicin induced cell death in large part through the suppression of autophagy. This sensitization was observed in all the HCC tested, but not in normal human liver cell line, suggesting that Rg3 synergism with doxorubicin is selective to cancer cells. The minimal amount of caspase-3 cleavage was seen in some of the drying cells treated with Rg3 and doxorubicin when compared to the TRAlL induced caspase-3 cleavage. Thus, Rg3 and doxorubicin-induced cell death seems to be a largely a caspase-independent process.
