Part Used : ไม่ระบุ
Activity : ANTITUMOR ACTIVITY
Solvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : 20 mg/kg Rg3, in phosphate-buffed saline
Duration : 21 days
Type of interaction : Pharmacodynamics
Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : 1 mg/kg, 3 times/weks
Remark : Rg3 or doxorubicin treatment alone had minimal effect on the growth of tumors at the doses used, with the tumor size similar to the control mice. Notably, combined treatment with Rg3 and doxorubicin led to significant reduction of the tumor volume on xenograft model mouse. Consistent with the data on tumor volume, the tumor weight was also significantly decreased in combination of Rg3 and doxorubicin. The tumors from mice treated with the Rg3-doxorubicin combination showed that the cell density was greatly lower than in the Rg3-or doxorubicin-only groups.
Type of animal: Male, 6-week-old nude mice.