ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : APOPTOSIS INDUCTION

Solvent/Active Compound : water

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 100 microgram/ml

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : Imatinib*/Glivec/Imatinib mesylate

Dose/Conc.(drug) : 0.1 micromolar

Result : Positive

Remark : Treated KBM-5, K562, THP-1, U266, and MM1.S cells with KRGE in combination with IM for 24 h, and then examined the cell viability with an MTT assay. The results found that KRGE indeed enhanced the cytotoxic effects of IM only in KBM-5 cells. The combination treatment indeed enhanced apoptosis by activation of caspase-3 and induced PARP cleavage, suppressed antiapoptosis and proliferative proteins expression, decreased the phosphorylation of p38, STAT5, and p53 in KBM-5 cells and inhibited STAT5-DNA binding activities. These results show that KRGE and IM can abrogate the DNA binding ability of STAT5.

Note : Imatinib mesylate = IM

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