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Part Used : รากActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : Non-saponin fraction (NSF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Thrombin 0.1 units/ml + NSF 20 mcg/mlDuration : 2 min at 37 degree CelsiusType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: NSF 20 mcg/ml inhibited platelet aggregation 78.8%Note : - Platelet-rich plasma obtained from the antecubital vein of normal healthy human volunteers. - Platelet aggregation was induced by thrombin 0.1 units/ml. - Verapamil 1 micromolar + thrombin 0.1 units/ml inhibited platelet aggregation 56.7%
Part Used : รากActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : Non-saponin fraction (NSF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Thrombin 0.1 units/ml + NSF 30 mcg/mlDuration : 2 min at 37 degree CelsiusType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: NSF 30 mcg/ml inhibited platelet aggregation 83.2%Note : - Platelet-rich plasma obtained from the antecubital vein of normal healthy human volunteers. - Platelet aggregation was induced by thrombin 0.1 units/ml. - Verapamil 1 micromolar + thrombin 0.1 units/ml inhibited platelet aggregation 56.7%
Part Used : รากActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : Non-saponin fraction (NSF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Thrombin 0.1 units/ml + NSF 10 mcg/mlDuration : 2 min at 37 degree celsiusType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: NSF 10 mcg/ml inhibited platelet aggregation 70.3%Note : - Platelet-rich plasma obtained from the antecubital vein of normal healthy human volunteers. - Platelet aggregation was induced by thrombin 0.1 units/ml. - Verapamil 1 micromolar + thrombin 0.1 units/ml inhibited platelet aggregation 56.7%
Part Used : รากActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : a lipophilic fraction (LF)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : basal diet containing 15% corn oil plus LF 25 mg (0.0025% by total diets)Duration : 3 weeksType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The dietary LF regulates the levels of cGMP, and cAMP and prolongs the time interval (thrombin time, activated partial thromboplastin time) between the conversion of fibrinogen to fibrin.
