| Synonym |
| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ginsenoside Rg1, ginsenoside Re, notoginsenoside R1, ginsenosides Rb1, Rc, RdType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarDuration : The incubation time was set at 5 minType of interaction : PharmacokineticsInteraction with drug : Oestradiol-17beta-D-glucuronide*/Estradiol-17beta-D-glucuronide*/Estradiol glucuronideDose/Conc.(drug) : 10 micromolarResult : PositiveRemark : Result: The ppt-type ginsenoside Rg1, ginsenoside Re and notoginsenoside R1 were found to be substrates of human OATP1B3, rather than those of human OATP1B1. Ginsenosides Rb1, Rc and Rd were not transported by OATP1B3 and OATP1B1. The ppt-type ginsenoside Rg1, ginsenoside Re and notoginsenoside R1 exhibited weak inhibitory properties towards the OATP1B transporters (IC50 values > 39 micromolar).
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ginsenoside Rg1, ginsenoside Re, notoginsenoside R1, ginsenosides Rb1, Rc, RdType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micromolarDuration : The incubation time was set at 5 minType of interaction : PharmacokineticsInteraction with drug : Oestradiol-17beta-D-glucuronide*/Estradiol-17beta-D-glucuronide*/Estradiol glucuronideDose/Conc.(drug) : 10 micromolarResult : PositiveRemark : Result: However, these ATP-binding cassette (ABC) transporters exhibited little or no activity towards the transports of the ppd-type ginsenosides Rb1, Rc and Rd. The ppd-type ginsenosides did not exhibit any significant inhibitory activity towards these ABC transporters. This was indicated by 100 micromolar ginsenosides producing only 7.3-21.3% inhibition of transport activities of MRP2 (oestradiol-17beta-D-glucuronide), BCRP (methotrexate) and BSEP (taurocholic acid).
