ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : DRUG INTERACTION

Solvent/Active Compound : ginsenoside Rg1, ginsenoside Re, notoginsenoside R1, ginsenosides Rb1, Rc, Rd

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 100 micromolar

Duration : The incubation time was set at 5 min

Type of interaction : Pharmacokinetics

Interaction with drug : Methotrexate*/Amethopterin/MTX

Dose/Conc.(drug) : 10 micromolar

Result : Positive

Remark : Result: However, these ATP-binding cassette (ABC) transporters exhibited little or no activity towards the transports of the ppd-type ginsenosides Rb1, Rc and Rd. The ppd-type ginsenosides did not exhibit any significant inhibitory activity towards these ABC transporters. This was indicated by 100 micromolar ginsenosides producing only 7.3-21.3% inhibition of transport activities of MRP2 (oestradiol-17beta-D-glucuronide), BCRP (methotrexate) and BSEP (taurocholic acid).

---