ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : Panax ginseng (PG) suspension

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : gastric gavage feeding of PG suspension 150 mg/kg/day

Duration : 14 consecutive days

Type of interaction : Pharmacokinetics

Interaction with drug : Fexofenadine

Dose/Conc.(drug) : -

Result : Positive

Remark : A single dose of fexofenadine (100 mg/kg for oral dose) was administered after 14 days of feeding PGS. Blood samples were collected from 0 to 12 h. and levels of fexofenadine were measured by LC-MS/MS. Result: PG deoreased the AUC between 0-12h, decreased Cmax, and decreased ratios of brain to plasma concentration. The mean bioavailability of fexofenadine was decreased by 16.1%.

Note : Long term administration of Panax ginseng to rats might induce both intestinal and brain endothelium p-glycoprotein expression. In addition, long term use of Panax ginseng reduced the bioavailability of concurrently administered fexofenadine.

---