| Synonym |
| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ginsenoside Rg1 (protopanaxatriol-type saponin)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5-20 micromolar of Rg1Duration : 2 h in a CO2 incubatorType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : NegativeRemark : Result: Rg1 did not have any effects on the accumulation of P-gp substrate daunorubicin.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : The hydrolyzed metabolites of ginsenosides M4Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar of M4Duration : 2 h in a CO2 incubatorType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : PositiveRemark : Result: M4 significantly increased the accumulation of P-gp substrate daunorubicin 3.6-fold, to a similar extent in the presence of 20 micromolar cyclosporine A. At higher concentrations the accumulation decreased. No stimulation effects were observed for these ginsenoside metabolites on the cellular accumulation of daunorubicin in drug-sensitive KB3-1 cells.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : The hydrolyzed metabolites of ginsenosides M4Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10 micromolar of M4Duration : 2 h in a CO2 incubatorType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : PositiveRemark : Result: M4 significantly increased the accumulation of P-gp substrate daunorubicin 3.6-fold, to a similar extent in the presence of 20 micromolar cyclosporine A. At higher concentrations the accumulation decreased. No stimulation effects were observed for these ginsenoside metabolites on the cellular accumulation of daunorubicin in drug-sensitive KB3-1 cells.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : The hydrolyzed metabolites of ginsenosides M1Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar of M1Duration : 2 h in a CO2 incubatorType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : PositiveRemark : Result: M1 increased the accumulation of P-gp substrate daunorubicin, but the effects were less than that of M4.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : The hydrolyzed metabolites of ginsenosides M12Type of experiment : in vitroType of animal : -Type of study : -N(Total) : NSN(Treatment) : NSSex : -Age : NSRoute : -Dose/Conc.(herb) : 5 micromolar of M12Duration : 2 h in a CO2 incubatorType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : PositiveRemark : Result: M12 increased the accumulation of P-gp substrate daunorubicin, but the effects were less than that of M4.
