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Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The time to reach the maximum concentration (Tmax) was 14.56 min in the PGS pretreated groups, and 10.37 min in the control gruop. After pretreatment with PGS, the elimination half-life of 5-FU was significantly increased from 79.17 to 125.72, which was an increase of approximately 58.8% compared with the control. The results indicate that PGS may affect the elimination of 5-FU.
Part Used : รากActivity : PHARMACOKINETIC ALTERATIONSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The time to reach the maximum concentration (Tmax) was 14.56 min in the PGS pretreated groups, and 10.37 min in the control gruop. After pretreatment with PGS, the elimination half-life of 5-FU was significantly increased from 79.17 to 125.72, which was an increase of approximately 58.8% compared with the control. The results indicate that PGS may affect the elimination of 5-FU.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The time to reach the maximum concentration (Tmax) was 14.56 min in the PGS pretreated groups, and 10.37 min in the control gruop. After pretreatment with PGS, the elimination half-life of 5-FU was significantly increased from 79.17 to 125.72, which was an increase of approximately 58.8% compared with the control. The results indicate that PGS may affect the elimination of 5-FU.
Part Used : รากActivity : CYTOTOXIC ACTIVITYSolvent/Active Compound : Panax ginseng (PGS) water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PGS extract 0.81 g/kg, twice dailyDuration : ten consecutive daysType of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Result: The combination of 5-FU and PGS did not show a synergistic inhibitory effect on three different cancer lines (A549, BIU-87 and SW480). The results indicate that the observed cytotoxicity was primarily generated by 5-FU alone. But the combination of 5-FU and PGS showed a synergistic inhibitory effect on BGC823 (human gastric cancer cell line) but not on GES-1 (human normal gastric epithelial cell line).
