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ARALIACEAE Panax ginseng C.A. Mey.

Synonym

none ...

Thai / English name

โสม*

[1-3] of 3 article(s) found

หน้า 1

[1] PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER AND ANTI-CANCER ADJUVANT COMPRISING CYCLOPHOSPHAMIDE AND RED GINSENG ACIDIC POLYSACCHARIDE IN COMBINATION WITH MAXIMIZING ACTIVITY.
KWAK YS,KIM YS,SHIN HJ,ET AL.
REPUB KOREAN KONGKAE TAEHO KONGBO KR 2006025213 2006 Vol.(), 330507 [Abstract]

Part Used : เหง้า
Activity : DRUG INTERACTION

Solvent/Active Compound : red ginseng acidic polysaccharide

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Cyclophosphamide*/CPM/CTX/CYT
Dose/Conc.(drug) : -

Result : Positive

Remark : The red ginseng acidic polysaccharide consists of 41.5-61.5% of glucuronic acid, 3.9-5.9% of galacturonic acid, 15.1-35.1% of glucose, and 0.5-2.5% of arabinose and has a molecular weight of 12,000-450,000 Da.

Note : Data incomplete.

[2] EFFECT OF GINSENG SAPONIN, ARSENIC TRIOXIDE, BETA-ELEMENE COMBINED WITH CTX ON TELOMERE-TELOMERASE SYSTEM IN K562 CELL LINE.
WANG Y,FANG M
ZHONGGUO SHIYAN XUEYEXUE ZAZHI 2006 Vol.14(6),1089-95 397604 [Abstract]

Part Used : ดอก
Activity : DRUG INTERACTION

Solvent/Active Compound : saponin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : 24-72 hours
Type of interaction : Pharmacodynamics

Interaction with drug : Cyclophosphamide*/CPM/CTX/CYT
Dose/Conc.(drug) : -

Result : Positive

Remark : - Study in Human erythroleukemic cell line K562. - Ginseng saponin could completely inhibit the telomerase activity of K562 cells at proper concentration and exposure time and the inhibiting effects were enhanced when used in combination with cyclophosphamide.

Note : Data incomplete

[3] X-RAY STRUCTURE INVESTIGATION OF (20S)-20-O-BETA-D-GLUCOPYRANOSYL-PROTOPANAXADIOL AND ANTITUMOR EFFECT ON LEWIS LUNG CARCINOMA IN VIVO.
ZHOU W,FENG M,LI X,ET AL.
CHEM BIODIVERS 2009 Vol.6(3),380-8 451392 [Abstract]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : (20S)-20-O-beta-D-Glucopyranosyl-protopanaxadiol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Cyclophosphamide*/CPM/CTX/CYT
Dose/Conc.(drug) : -

Result : Positive

Remark : Comparing the antitumor activity of (20S)-20-O-beta-D-Glucopyranosyl-protopanaxadiol (1) plus cyclophosphamide (CTX) with that of CTX alone, the combination effect was significantly superior and synergistic. This may due to immunoregulation activity of 1 by improving the WBC, IL-2 and INF-gamma degraded by CTX.

Note : Data from abstract

หน้า 1

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