| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 micromolarDuration : lncubation for 30 minType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 2.5 micromolarResult : PositiveRemark : Rg3 is able to sensitize hepatocellular carcinoma cell (HCC) to doxorbicin induced cell death in large part through the suppression of autophagy. This sensitization was observed in all the HCC tested, but not in normal human liver cell line, suggesting that Rg3 synergism with doxorubicin is selective to cancer cells. The minimal amount of caspase-3 cleavage was seen in some of the drying cells treated with Rg3 and doxorubicin when compared to the TRAlL induced caspase-3 cleavage. Thus, Rg3 and doxorubicin-induced cell death seems to be a largely a caspase-independent process.
Part Used : ไม่ระบุActivity : CYTOTOXIC ACTIVITYSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 micromolarDuration : lncubation for 30 minType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 2.5 micromolarResult : PositiveRemark : Rg3 is able to sensitize hepatocellular carcinoma cell (HCC) to doxorbicin induced cell death in large part through the suppression of autophagy. This sensitization was observed in all the HCC tested, but not in normal human liver cell line, suggesting that Rg3 synergism with doxorubicin is selective to cancer cells. The minimal amount of caspase-3 cleavage was seen in some of the drying cells treated with Rg3 and doxorubicin when compared to the TRAlL induced caspase-3 cleavage. Thus, Rg3 and doxorubicin-induced cell death seems to be a largely a caspase-independent process.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kg Rg3, in phosphate-buffed salineDuration : 21 daysType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 1 mg/kg, 3 times/weksResult : PositiveRemark : Rg3 or doxorubicin treatment alone had minimal effect on the growth of tumors at the doses used, with the tumor size similar to the control mice. Notably, combined treatment with Rg3 and doxorubicin led to significant reduction of the tumor volume on xenograft model mouse. Consistent with the data on tumor volume, the tumor weight was also significantly decreased in combination of Rg3 and doxorubicin. The tumors from mice treated with the Rg3-doxorubicin combination showed that the cell density was greatly lower than in the Rg3-or doxorubicin-only groups. Type of animal: Male, 6-week-old nude mice.
Part Used : ไม่ระบุActivity : TUMOR PROMOTION INHIBITIONSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kg Rg3, in phosphate-buffed salineDuration : 21 daysType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 1 mg/kg, 3 times/weksResult : PositiveRemark : Rg3 or doxorubicin treatment alone had minimal effect on the growth of tumors at the doses used, with the tumor size similar to the control mice. Notably, combined treatment with Rg3 and doxorubicin led to significant reduction of the tumor volume on xenograft model mouse. Consistent with the data on tumor volume, the tumor weight was also significantly decreased in combination of Rg3 and doxorubicin. The tumors from mice treated with the Rg3-doxorubicin combination showed that the cell density was greatly lower than in the Rg3-or doxorubicin-only groups. Type of animal: Male, 6-week-old nude mice.
Part Used : ไม่ระบุActivity : ANTITUMOR ACTIVITYSolvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kg Rg3, in phosphate-buffed salineDuration : 21 daysType of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 1 mg/kg, 3 times/weksResult : PositiveRemark : Rg3 or doxorubicin treatment alone had minimal effect on the growth of tumors at the doses used, with the tumor size similar to the control mice. Notably, combined treatment with Rg3 and doxorubicin led to significant reduction of the tumor volume on xenograft model mouse. Consistent with the data on tumor volume, the tumor weight was also significantly decreased in combination of Rg3 and doxorubicin. The tumors from mice treated with the Rg3-doxorubicin combination showed that the cell density was greatly lower than in the Rg3-or doxorubicin-only groups. Type of animal: Male, 6-week-old nude mice.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginsenoside Rg3Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 10 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 15 mg/kg; i.p.Result : PositiveRemark : Type of experiment: The rats were treated with adriamycin (ADM) or a combination of ADM and Ginsenoside Rg3 (Rg3; 10, 20, and 40 mg/kg for 14 days. Results: Rg3 could ameliorate the decrease in the ejection fraction and fractional shortening that was induced by ADM, and improve the left ventricular outflow. The aortic ring assay showed that Rg3 could partially recover the abnormal vascular function.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginsenoside Rg3Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 15 mg/kg; i.p.Result : PositiveRemark : Type of experiment: The rats were treated with adriamycin (ADM) or a combination of ADM and Ginsenoside Rg3 (Rg3; 10, 20, and 40 mg/kg for 14 days. Results: Rg3 could ameliorate the decrease in the ejection fraction and fractional shortening that was induced by ADM, and improve the left ventricular outflow. The aortic ring assay showed that Rg3 could partially recover the abnormal vascular function.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginsenoside Rg3Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 40 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : 15 mg/kg; i.p.Result : PositiveRemark : Type of experiment: The rats were treated with adriamycin (ADM) or a combination of ADM and Ginsenoside Rg3 (Rg3; 10, 20, and 40 mg/kg for 14 days. Results: Rg3 could ameliorate the decrease in the ejection fraction and fractional shortening that was induced by ADM, and improve the left ventricular outflow. The aortic ring assay showed that Rg3 could partially recover the abnormal vascular function.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginsenoside Rg3Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Cardiac microvascular endothelial cells (CMEC) from neonatal rats. Results: Ginsenoside Rg3 could promote cell viability to attenuate ADM induced oxidative damage and apoptosis. This counteraction was achieved partially via activation of the Nrf2-ARE pathway through the activation of Akt.
