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| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Dry extract/ginsenosides (T-ginseng)Type of experiment : in vivoType of animal : guinea pigType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : (a) injecting guinea pigs with a mixture of T-ginseng and inactivated porcine parvovirus (PPV) as a conventional vaccine.Duration : -Type of interaction : PharmacokineticsInteraction with drug : VaccineDose/Conc.(drug) : -Result : PositiveRemark : Result: T-ginseng and Al(OH)3 acted synergistically and further improved the antibody response to the PPV-antigen to 6826+/- 2413, i.e. more than 20 times the Hl titre of the non-adjvanted PPV-vaccine. Immunisations using PPV-vaccines adjuvanted with single purified G-des demonstrated that the ginseng fractions Rb1 and Rg1 are potent adjuvants inducing higher or similar antibody titres than the vaccine adjuvanted with Al(OH)3, e.g. Rb1 tested at a concentration of 830 micrograms per dose induced a higher antibody titre than the one adjuvanted with Al(OH)3. Nevertheless, different than the mixture Al(OH)3-T-ginseng; Rb1 and Rg1 act antagonistically and partially inhibit each other. The G-des adjuvanted vaccines induced higher titres of IgG2 antibodies compared with IgG1.Note : PPV = inactivated porcine parvovirus HI = haemagglutination inhibition test G-des = ginsenosides
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Dry extract/ginsenosides (T-ginseng)Type of experiment : in vivoType of animal : guinea pigType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : (b) injecting PPV-antigen and T-ginseng simultaneously but separately at different sites on the animal.Duration : -Type of interaction : PharmacokineticsInteraction with drug : VaccineDose/Conc.(drug) : -Result : PositiveRemark : Result: T-ginseng and Al(OH)3 acted synergistically and further improved the antibody response to the PPV-antigen to 6826+/- 2413, i.e. more than 20 times the Hl titre of the non-adjvanted PPV-vaccine. Immunisations using PPV-vaccines adjuvanted with single purified G-des demonstrated that the ginseng fractions Rb1 and Rg1 are potent adjuvants inducing higher or similar antibody titres than the vaccine adjuvanted with Al(OH)3, e.g. Rb1 tested at a concentration of 830 micrograms per dose induced a higher antibody titre than the one adjuvanted with Al(OH)3. Nevertheless, different than the mixture Al(OH)3-T-ginseng; Rb1 and Rg1 act antagonistically and partially inhibit each other. The G-des adjuvanted vaccines induced higher titres of IgG2 antibodies compared with IgG1.Note : PPV = inactivated porcine parvovirus HI = haemagglutination inhibition test G-des = ginsenosides
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Dry extract/ginsenosides (T-ginseng)Type of experiment : in vivoType of animal : guinea pigType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : (c) injecting only the T-ginseng 1 or 2 weeks prior to immunisation with the PPV-antigen.Duration : -Type of interaction : PharmacokineticsInteraction with drug : VaccineDose/Conc.(drug) : -Result : PositiveRemark : Result: T-ginseng and Al(OH)3 acted synergistically and further improved the antibody response to the PPV-antigen to 6826+/- 2413, i.e. more than 20 times the Hl titre of the non-adjvanted PPV-vaccine. Immunisations using PPV-vaccines adjuvanted with single purified G-des demonstrated that the ginseng fractions Rb1 and Rg1 are potent adjuvants inducing higher or similar antibody titres than the vaccine adjuvanted with Al(OH)3, e.g. Rb1 tested at a concentration of 830 micrograms per dose induced a higher antibody titre than the one adjuvanted with Al(OH)3. Nevertheless, different than the mixture Al(OH)3-T-ginseng; Rb1 and Rg1 act antagonistically and partially inhibit each other. The G-des adjuvanted vaccines induced higher titres of IgG2 antibodies compared with IgG1.Note : PPV = inactivated porcine parvovirus HI = haemagglutination inhibition test G-des = ginsenosides
