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Part Used : ไม่ระบุActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : GinsenosidesType of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOI's nifedipine, and in cancer chemotherapy.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : GinsenosidesType of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOI's nifedipine, and in cancer chemotherapy.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound :Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data from review, data incomplete.
