| Synonym |
| Thai / English name |
Part Used : รากActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : 20(S)-ginsenoside F1 (20(S)-GF1), ginsenoside Rh1(Rh1)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : 20(S)-ginsenoside F1 (20(S)-GF1), ginsenoside Rh1(Rh1)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Asian or Siberian ginsengType of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : NegativeRemark : Result: Serum pools prepared from samples from patients receiving digoxin and then supplemented with Asian or Siberian ginseng showed falsely increased digoxin values using the fluorescence polarization immunoassay (FPIA) falsely decreased values using the microparticle enzyme immunoassay (MEIA). Digoxin-like immunoreactive substances (DLISs) showed synergistic effects with ginsengs in interfering with the FPIA and MEIA for digoxin. No interference was observed with 3 other digoxin assays, even in the presence of elevated DLISs.Note : Data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: When aliquots of a digoxin pool prepared from patients receiving digoxin were supplemented with these Chinese medicines, the most significant interference with the fluorescence polarization immunoassay (FPIA) was observed. The presence of endogenous digoxin-like immunoreactive substances can have additive effects with these Chinese medicines and falsely increase apparent digoxin levels by the FPIA. On the other hand, the Roche and Beckman assays were free from interference from DLIS but showed significant interference from Chan Su and Lu-Shen-Wan.Note : Data incomplete.
